纯度:95% by HPLC;NMR (Conforms)
分子式:C8H9N5
分子量:175.19
溶剂:DMSO (50 mg/ml) Water (4 mg/ml)
性状:Beige solid
存储:RT
Activity (short version):Hv1 channel blocker
Function / Pharmacology:A selective and state-dependent blocker of voltage-gated proton channels (Hv1).1 2GBI blocks the channel by binding to the voltage-sensing domain from its intracellular side.2,3 Inhibition of Hv1 is a potentially new target of intervention in various pathophysiological processes including inflammatory, cancer, bone resorption and neurodegenerative disease.4