纯度:98% by HPLC;NMR (Conforms)
分子式:C9H10N2O
分子量:162.19
溶剂:DMSO (50 mg/ml) Ethanol (30 mg/ml)
性状:Crystalline solid
存储:RT
Activity (short version):K+ channel activator; Cardiomyocyte differentiation
Function / Pharmacology:A direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessels.1 Reverses ischemia-induced cognitive impairment2 and displays neuroprotective effects in ischemia-induced neuronal cell death3. Induces embryonic stem cell differentiation into cardiomyocytes and enrichment of pacemaker-like cells.4 Induces production of superoxide and hydrogen peroxide in neutrophils with subsequent apoptosis.5