纯度:98% by TLC,;NMR (Conforms)
分子式:C27H45NO
分子量:399.65
溶剂:DMSO (20 mg/ml) Ethanol (25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Neurotrophic agent
Function / Pharmacology:Neuroregenerative and neuroprotective agent acting at components of the mitochondrial permeability transition pore (MPTP).1 Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in mice. Reduces ROS and NLRP3 inflammasome activation in a mouse model of intracerebral hemorrhage.2 Inhibits MPTP opening and protects neurons from apoptosis.3 Induces oligodendrocyte maturation in culture and promotes myelin regeneration in vivo in a rodent model.4