纯度:98% by HPLC
分子式:C18H22N4O6S4
分子量:518.65
溶剂:DMSO (50 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):Glutathione and thioredoxin reductase inhibitor
Function / Pharmacology:Inhibits glutathione reductase and thioredoxin reductase,IC50s=6.7 and 8.7 μM respectively, and impairs mitochondrial function.1 May be used to induce a cellular model of thiol oxidative stress.2 Enhances sensitivity of cancer cell lines to X-ray irradiation.3 Induces G2/M cell cycle arrest by inducing thiol oxidative stress resulting in α-tubulin S-glutathionylation-mediated microtubule depolymerization.4 Improves limb revascularization by glutathionylation and subsequent stabilization of HIF-1α.5