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Nintedanib
- 英文名称:Nintedanib
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10914
- cas:656247-17-5
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10914 |
用途 | 科研检测 |
英文名称 | Nintedanib |
包装规格 | 1MG |
CAS编号 | 656247-17-5 |
别名 | Nintedanib |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C31H33N5O4
分子量:539.64
溶剂:DMSO (4 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):VEGFR, PDGFR and FGFR kinase inhibitor
Function / Pharmacology:Nintedanib is a potent inhibitor of VEGFR, PDGFR, FGFR (IC50 = 13-34 nM for VEGFR, 59-65 nM for PDGFR and 37-108 nM for FGFR subtypes).1 Also inhibits Flt-3, Lck, Lyn and Src (IC50 = 16-156 nM). Inhibits VEGF-stimulated proliferation of HUVECs.1 Inhibits tumor growth in a mouse tumor xenograft model.1 A novel therapeutic agent for treatment of idiopathic pulmonary fibrosis.2,3 Alleviates chronic pancreatitis by inhibiting the activation of pancreatic stellate cells.4
分子式:C31H33N5O4
分子量:539.64
溶剂:DMSO (4 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):VEGFR, PDGFR and FGFR kinase inhibitor
Function / Pharmacology:Nintedanib is a potent inhibitor of VEGFR, PDGFR, FGFR (IC50 = 13-34 nM for VEGFR, 59-65 nM for PDGFR and 37-108 nM for FGFR subtypes).1 Also inhibits Flt-3, Lck, Lyn and Src (IC50 = 16-156 nM). Inhibits VEGF-stimulated proliferation of HUVECs.1 Inhibits tumor growth in a mouse tumor xenograft model.1 A novel therapeutic agent for treatment of idiopathic pulmonary fibrosis.2,3 Alleviates chronic pancreatitis by inhibiting the activation of pancreatic stellate cells.4