纯度:95% by HPLC,;NMR (Conforms)
分子式:C15H20O5
分子量:280.32
溶剂:Water (1 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Glyceraldehyde-3-phosphate dehydrogenase inhibitor
Function / Pharmacology:Koningic acid (KA) is a potent and selective inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH).1 Inhibition is irreversible and proceeds via nucleophilic attack of an active site cysteine on the epoxide moiety2, Ki = 1.1 μM for rabbit muscle GAPDH3. KA can selectively kill high-glycolytic cancer cells via glucose dependent ATP depletion.4 Has been used in a predictive model for selective targeting of the Warburg effect, the most prominent hallmark of cancer cell metabolism.5