纯度:>98% by HPLC,;NMR (Conforms)
分子式:C14H12N4O
分子量:
溶剂:DMSO (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):TLR8 antagonist
Function / Pharmacology:CU-CPT8m is a potent and selective antagonist of toll-like receptor 8 (TLR8) acting via stabilization of the TLR8 homodimer.1 It inhibits TNFα and IL-8 expression induced by the TLR8 agonist resiquimod at 1 mM and suppresses TLR8-mediated proinflammatory signaling in various cell lines, human primary cells and patient specimens. It reverses phenotypes involved in TLR8-activating fibroblasts.2 CU-CPT8m promotes erythroid cell proliferation and differentiation.3