纯度:98% by TLC;NMR (Conforms)
分子式:C15H13ClN2OS
分子量:304.79
溶剂:DMSO (45 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):GPR142 antagonist
Function / Pharmacology:GPR142 is highly expressed in the pancreas and immune system and shares 33% homology with GPR1391. Endogenous agonists identified to date include aromatic amino acids such as tryptophan and phenylalanine2. CLP-3094 was identified as a potent and selective GPR142 antagonist with an IC50=2.3 ?M against 1 mM L-tryptophan. It inhibited insulin secretion from islets induced by L-tryptophan and other agonists and displayed anti-inflammatory activity in a mouse arthritis model.3