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GSK126
- 英文名称:GSK126
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10926
- cas:1346574-57-9
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10926 |
用途 | 科研检测 |
英文名称 | GSK126 |
包装规格 | 1MG |
CAS编号 | 1346574-57-9 |
别名 | GSK126 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC/TLC,;NMR (Conforms)
分子式:C31H38N6O2
分子量:526.69
溶剂:DMSO (16 mg/ml)
性状:Cream colored solid
存储:-20°C
Activity (short version):EZH2 methyltransferase inhibitor
Function / Pharmacology:Potent, selective, S-adenosyl-methionine-competitive inhibitor of EZH2 methyltransferase, Ki=0.5-3 nM, >150-fold selective for EZH2 over EZH1 and >1000-fold selective over 20 methyltransferases.1 Decreases global H3K27me3 levels and reactivates silenced PRC2 target genes. GSK-126 inhibits proliferation of diffuse large B-cell lymphoma (DLBCL) cell lines as well as DLBCL xenografts in mice.1 Rescues exhausted CD8+ T cells in HCV infection.2 Facilitates the transition of embryonic stem cells to feeder-free extended pluripotent stem cells in combination with a cocktail of other agents.3 Displays neuroprotective effects in ischemic brain injury in a rodent model.4
分子式:C31H38N6O2
分子量:526.69
溶剂:DMSO (16 mg/ml)
性状:Cream colored solid
存储:-20°C
Activity (short version):EZH2 methyltransferase inhibitor
Function / Pharmacology:Potent, selective, S-adenosyl-methionine-competitive inhibitor of EZH2 methyltransferase, Ki=0.5-3 nM, >150-fold selective for EZH2 over EZH1 and >1000-fold selective over 20 methyltransferases.1 Decreases global H3K27me3 levels and reactivates silenced PRC2 target genes. GSK-126 inhibits proliferation of diffuse large B-cell lymphoma (DLBCL) cell lines as well as DLBCL xenografts in mice.1 Rescues exhausted CD8+ T cells in HCV infection.2 Facilitates the transition of embryonic stem cells to feeder-free extended pluripotent stem cells in combination with a cocktail of other agents.3 Displays neuroprotective effects in ischemic brain injury in a rodent model.4