纯度:>98% by TLC;NMR (Conforms)
分子式:C17H16N2O3
分子量:296.33
溶剂:DMSO (50 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):HDAC8 inhibitor
Function / Pharmacology:PCI-34051 is a potent and selective HDAC8 inhibitor (IC50=10 nM) with greater than 200-fold selectivity over HDACs 1, 2, 3, 6, 10.1 Unlike broad-spectrum HDAC inhibitors, it does not cause detectable histone or tubulin acetylation.1 Studies employing PCI-34051 showed that HDAC8 catalyzes the hydrolysis of long chain fatty acyl lysine.2 It is a very useful tool for exploring the role of HDAC8 in cellular function.3-6