纯度:>98% by TLC;NMR (Conforms)
分子式:C22H19Br2FN2O
分子量:506.21
溶剂:DMSO (40 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):NAMPT activator / Proneurogenic agent
Function / Pharmacology:P7C3-A20 is a neuroprotective and proneurogenic agent acting via NAMPT stimulation.1 Displays neuroprotective and promotes endogenous reparative functions after traumatic brain injury (TBI).2 Furthermore it repairs the blood-brain barrier, arrests chronic neurodegeneration and restores cognition after TBI in a mouse model.3 P7C3-A20 exerts neuroprotective effects in a hypoxic-ischemic encephalopathy model.4 Suppresses neuroinflammation and protects retinal ganglion cells from optic nerve crush in a rat model.5