纯度:98% by HPLC;NMR (Conforms)
分子式:C24H26O6
分子量:410.46
溶剂:DMSO (50 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):STING agonist (human)
Function / Pharmacology:α-Mangostin is a xanthone natural product that has historically been used in traditional folk medicine.1 It is a potent agonist of human STING (Stimulator of Interferon Genes) and also weakly activates mouse STING.2 Induces IFN-? production and repolarizes human monocyte-derived M2 macrophages to M1. Improves insulin secretion and protects INS-1 cells from streptozotocin-induced damage.3 Suppresses the metastasis of human renal carcinoma cells.4 Synergizes with kinase inhibitors in suppression of proliferation of SK-MEL-2 malignant melanoma cells.5