纯度:98% by TLC;NMR (Conforms)
分子式:C14H8O4
分子量:240.21
溶剂:DMSO (20 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):STAT3 inhibitor / Cancer cell stemness inhibitor
Function / Pharmacology:Inhibits gene transcription driven by STAT3. Inhibits cancer cell stemness gene expression and blocks spherogenesis of stemness-high cancer cells isolated from a variety of cancer types.1 Effective antitumor agent as a monotherapy or in combination with other agents such as taxol in mouse models.2 Clinical trials have demonstrated encouraging anti-tumor activity with the potential to suppress metastasis and prevent relapse in patients with various types of cancer.2,3 Overcomes cisplatin resistance in non-small cell lung cancer.4