纯度:>98% by HPLC;NMR (Conforms)
分子式:C14H11ClN6O3
分子量:346.73
溶剂:DMSO (30 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Autophagy inhibitor
Function / Pharmacology:Inhibits autophagy induced by starvation or rapamycin by inhibiting the lipid kinase VPS34 (IC50=19 nM).1 Increased autophagy and apoptosis were rescued by autophinib in Per1-overexpressing oral squamous cell carcinoma cells.2 Autophinib has quickly become an important biochemical tool for inhibition of autophagy in a variety of cellular contexts.3-5