纯度:>95% HPLC,;NMR (Conforms)
分子式:C25H22N4O8
分子量:506.47
溶剂:DMSO
性状:Black solid
存储:-20°C
Activity (short version):Induces heterochromatin formation
Function / Pharmacology:Streptonigrin promotes heterochromatin formation at concentrations as low as 1 nM, a concentration at which there was no effect on proliferation or viability.1 Inhibits the SUMO-specific protease SENP1 resulting in increased global SUMOylation levels and reduced level of HIF1α.2 Stabilizes p53 via inhibition of transglutaminase 2 resulting in p53-mediated apoptosis in renal cell carcinoma cells.3 Cytotoxic to fast-cycling melanoma cells but leaves a small population of slow-dividing cells unaffected and may be considered a tool to enrich cultures with cells exhibiting melanoma stem cell characteristics.4