纯度:98% by TLC;NMR (Conforms)
分子式:C41H42N4O8
分子量:718.79
溶剂:DMSO (14 mg/ml)
性状:Black solid
存储:-20°C
Activity (short version):YAP inhibitor
Function / Pharmacology:Verteporfin inhibits transcription by YAP/TAZ, IC50 = 2.5 μM, (via disruption of YAP-TEAD interaction) inhibiting autophagy and halting proliferation of cancer and cancer stem cell lines.1,2 Inhibits autophagosome formation.3 Reverses differentiation of Src-overexpressing embryonic stem cells.4 May be used to ablate unwanted neovasculature in the eye, esophageal mucosa, and elsewhere using light to create damaging free radicals.5