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CPI-613
  • 英文名称:CPI-613
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B10948
  • cas:95809-78-2
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B10948
用途 科研检测
英文名称 CPI-613
包装规格 1MG
CAS编号 95809-78-2
别名 CPI-613
纯度 98+%
分子式
是否进口
纯度:98% by TLC;NMR (Conforms)
分子式:C22H28O2S2
分子量:388.59
溶剂:DMSO (30 mg/ml) Ethanol (20 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):KGDH and PDH inhibitor
Function / Pharmacology:Lipoic acid analog which potently disrupts mitochondrial metabolism with selectivity for tumor cells in vitro and shows strong antitumor activity in vivo.1 Inhibits alpha-ketoglutarate dehydrogenase (KGDH) by a redox mechanisms selectively in tumor cells.2 Inhibits pyruvate dehydrogenase (PDH) as a mechanistically distinct, non-redox, effect.1,2 A novel anticancer agent with a mitochondria-targeted mode of action with non-genotoxic propertie.3. Has been used (along with PS48) to induce a Warburg-like metabolic state in fibroblasts.4 Combination treatment of CPI-613 and chloroquine inhibits the progression of clear cell sarcoma in a mouse model.5
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