纯度:98% by HPLC,;NMR (Conforms)
分子式:C27H26FN3OS
分子量:459.58
溶剂:DMSO (25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):DAG Kinase inhibitor
Function / Pharmacology:R-59022 is a diacylglycerol kinase (DAGK) inhibitor, nonselective for DAGK isotypes (IC50=2.8 μM in intact platelets).1 Induces autophagy and apoptosis in NG108-15 neuronal cells via an mTOR-independent mechanism.2 Prevents conjugated linoleic acid-mediated inflammatory signaling and insulin resistance in human adipocytes.3 Blocks filovirus internalization in host cells.4