![]() |
IMR-1
- 英文名称:IMR-1
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10957
- cas:310456-65-6
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-16
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10957 |
用途 | 科研检测 |
英文名称 | IMR-1 |
包装规格 | 1MG |
CAS编号 | 310456-65-6 |
别名 | IMR-1 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC;NMR (Conforms)
分子式:C15H15NO5S2
分子量:353.41
溶剂:DMSO (45 mg/ml) Ethanol (9 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Notch transcriptional activation inhibitor
Function / Pharmacology:Inhibitor of Mastermind Recruitment-1 (IMR-1) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription1. IC50=26 ?M (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethylester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 ?M (in vitro assay). Binding of IMR-1 to NTC is non-covalent and reversible.1
分子式:C15H15NO5S2
分子量:353.41
溶剂:DMSO (45 mg/ml) Ethanol (9 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Notch transcriptional activation inhibitor
Function / Pharmacology:Inhibitor of Mastermind Recruitment-1 (IMR-1) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription1. IC50=26 ?M (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethylester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 ?M (in vitro assay). Binding of IMR-1 to NTC is non-covalent and reversible.1