纯度:>98% by TLC;NMR (Conforms)
分子式:C15H11Cl2NO4
分子量:340.16
溶剂:DMSO (35 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):TRPM4 blocker
Function / Pharmacology:CBA is a selective blocker of TRPM4 channels (IC50 = 1.5 mM) with no activity at TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a panel of other ion channels and receptors.1 Displays protective effects in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration.2 A highly useful tool for exploring the functions of TRM4 in a variety of cell types.3,4