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Neratinib
- 英文名称:Neratinib
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10963
- cas:698387-09-6
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-12
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10963 |
用途 | 科研检测 |
英文名称 | Neratinib |
包装规格 | 1MG |
CAS编号 | 698387-09-6 |
别名 | Neratinib |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C30H29ClN6O3
分子量:557.05
溶剂:DMSO (4 mg/ml, warm)
性状:White solid
存储:-20°C
Activity (short version):Dual EGFR and HER2 inhibitor
Function / Pharmacology:Neratinib is a potent, irreversible inhibitor of HER2/ErbB2 receptor tyrosine kinase and EGFR kinase (IC50’s= 59 nM and 92 nM, respectively). It suppresses receptor autophosphorylation and proliferation, blocks cell-cycle progression and inhibits HER2 signaling in of EGFR-dependent cancer cells and tumor xenograft models.1 Neratinib inhibits proliferation of gefitinib-resistant non-small cell lung cancer cells expressing mutant EGFR.2 Synergizes with dasatinib in HER2-positive cancer cells and xenografts.3 It’s been shown to also inhibit MST1 (IC50 = 37.7 nM).4
分子式:C30H29ClN6O3
分子量:557.05
溶剂:DMSO (4 mg/ml, warm)
性状:White solid
存储:-20°C
Activity (short version):Dual EGFR and HER2 inhibitor
Function / Pharmacology:Neratinib is a potent, irreversible inhibitor of HER2/ErbB2 receptor tyrosine kinase and EGFR kinase (IC50’s= 59 nM and 92 nM, respectively). It suppresses receptor autophosphorylation and proliferation, blocks cell-cycle progression and inhibits HER2 signaling in of EGFR-dependent cancer cells and tumor xenograft models.1 Neratinib inhibits proliferation of gefitinib-resistant non-small cell lung cancer cells expressing mutant EGFR.2 Synergizes with dasatinib in HER2-positive cancer cells and xenografts.3 It’s been shown to also inhibit MST1 (IC50 = 37.7 nM).4