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EGA
  • 英文名称:EGA
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B10966
  • cas:415687-81-9
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B10966
用途 科研检测
英文名称 EGA
包装规格 1MG
CAS编号 415687-81-9
别名 EGA
纯度 98+%
分子式
是否进口
纯度:>95% by TLC;NMR (Conforms)
分子式:C16H16BrN3O
分子量:346.23
溶剂:DMSO (50 mg/ml); Ethanol (10 mg/ml with warming)
性状:White solid
存储:-20°C
Activity (short version):Endosomal trafficking inhibitor
Function / Pharmacology:EGA is a novel selective inhibitor of endosomal trafficking which blocks cellular entry of lethal toxin and other acid-dependent bacterial toxins and viruses into mammalian cells.1 Inhibits Anthrax lethal toxin-induced RAW264.7 cell death, IC50=1.7 mM.1 Delays lysosomal targeting and degradation of the EGF receptor indicating that it targets host membrane trafficking.1 Does not block endosomal recycling of transferrin, retrograde trafficking of ricin, phagolysosomal trafficking or phagosome permeabilization by Franciscella tularensis, nor does it neutralize acidic organelles.1 Protects mammalian cells from Clostridium difficile CDT, Clostridium perfringens Iota toxin and Clostridium botulinum C2 toxin.2 A useful tool for exploring subcellular trafficking of various bacterial toxins.3
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