纯度:>98% by HPLC;NMR (Conforms)
分子式:C30H50O5
分子量:490.73
溶剂:DMSO (60 mg/ml) Ethanol (15 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Telomerase activator / Senolytic agent
Function / Pharmacology:Cycloastragenol is a novel naturally occurring terpenoid found in Astragalus which was shown to be a telomerase activator. In CD8+ T lymphocytes from HIV-infected donors it retarded telomere shortening, increased proliferative potential and enhanced cytokine/chemokine production and antiviral activity.1 It suppressed lung damage in a idiopathic pulmonary fibrosis mouse model.2 It has also been shown to be a novel senolytic agent, inducing senescent cell apoptosis and restoring physical function in mice with irradiation-induced aging.3