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DJ001
- 英文名称:DJ001
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10981
- cas:2161305-12-8
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-16
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10981 |
用途 | 科研检测 |
英文名称 | DJ001 |
包装规格 | 1MG |
CAS编号 | 2161305-12-8 |
别名 | DJ001 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by TLC;NMR (Conforms)
分子式:C15H12N2O3
分子量:268.27
溶剂:DMSO (50 mg/ml) Ethanol (10 mg/ml) Organic solvents such as chloroform (50 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):PTPsigma inhibitor / Promotes stem cell regeneration
Function / Pharmacology:DJ001 (2161306-12-8) is a potent and specific inhibitor of receptor type protein tyrosine phosphatase-sigma (PTP?) IC50=1.54 ?M and >10 ?M for 20 other phosphatases.1 Promotes hematopoietic stem cell regeneration in vivo. In mice treated with 5-fluorouricil or irradiated, DJ001 promoted HSC regeneration accelerated hematologic recovery and improved survival. The mode of inhibition of PTP? is via non-competitive allosteric binding. Suppression of radiation-induced HSC apoptosis occurs via activation of Rho GTPase, Rac1 and induction of BCL-XL. Treatment of irradiated human HSCs with DJ001 promotes the regeneration of human HSCs capable of multilineage in vivo repopulation.1
分子式:C15H12N2O3
分子量:268.27
溶剂:DMSO (50 mg/ml) Ethanol (10 mg/ml) Organic solvents such as chloroform (50 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):PTPsigma inhibitor / Promotes stem cell regeneration
Function / Pharmacology:DJ001 (2161306-12-8) is a potent and specific inhibitor of receptor type protein tyrosine phosphatase-sigma (PTP?) IC50=1.54 ?M and >10 ?M for 20 other phosphatases.1 Promotes hematopoietic stem cell regeneration in vivo. In mice treated with 5-fluorouricil or irradiated, DJ001 promoted HSC regeneration accelerated hematologic recovery and improved survival. The mode of inhibition of PTP? is via non-competitive allosteric binding. Suppression of radiation-induced HSC apoptosis occurs via activation of Rho GTPase, Rac1 and induction of BCL-XL. Treatment of irradiated human HSCs with DJ001 promotes the regeneration of human HSCs capable of multilineage in vivo repopulation.1