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DJ001
  • 英文名称:DJ001
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B10981
  • cas:2161305-12-8
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-16
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B10981
用途 科研检测
英文名称 DJ001
包装规格 1MG
CAS编号 2161305-12-8
别名 DJ001
纯度 98+%
分子式
是否进口
纯度:98% by TLC;NMR (Conforms)
分子式:C15H12N2O3
分子量:268.27
溶剂:DMSO (50 mg/ml) Ethanol (10 mg/ml) Organic solvents such as chloroform (50 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):PTPsigma inhibitor / Promotes stem cell regeneration
Function / Pharmacology:DJ001 (2161306-12-8) is a potent and specific inhibitor of receptor type protein tyrosine phosphatase-sigma (PTP?) IC50=1.54 ?M and >10 ?M for 20 other phosphatases.1 Promotes hematopoietic stem cell regeneration in vivo. In mice treated with 5-fluorouricil or irradiated, DJ001 promoted HSC regeneration accelerated hematologic recovery and improved survival. The mode of inhibition of PTP? is via non-competitive allosteric binding. Suppression of radiation-induced HSC apoptosis occurs via activation of Rho GTPase, Rac1 and induction of BCL-XL. Treatment of irradiated human HSCs with DJ001 promotes the regeneration of human HSCs capable of multilineage in vivo repopulation.1
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