纯度:98% by TLC;NMR (Conforms)
分子式:C15H12N2O3
分子量:268.27
溶剂:DMSO (50 mg/ml) Ethanol (10 mg/ml) Organic solvents such as chloroform (50 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):PTPsigma inhibitor / Promotes stem cell regeneration
Function / Pharmacology:DJ001 (2161306-12-8) is a potent and specific inhibitor of receptor type protein tyrosine phosphatase-sigma (PTP?) IC50=1.54 ?M and >10 ?M for 20 other phosphatases.1 Promotes hematopoietic stem cell regeneration in vivo. In mice treated with 5-fluorouricil or irradiated, DJ001 promoted HSC regeneration accelerated hematologic recovery and improved survival. The mode of inhibition of PTP? is via non-competitive allosteric binding. Suppression of radiation-induced HSC apoptosis occurs via activation of Rho GTPase, Rac1 and induction of BCL-XL. Treatment of irradiated human HSCs with DJ001 promotes the regeneration of human HSCs capable of multilineage in vivo repopulation.1