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JNJ-63533054
- 英文名称:JNJ-63533054
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10984
- cas:1802326-66-4
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10984 |
用途 | 科研检测 |
英文名称 | JNJ-63533054 |
包装规格 | 1MG |
CAS编号 | 1802326-66-4 |
别名 | JNJ-63533054 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C17H17ClN2O2
分子量:316.78
溶剂:DMSO (35 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):GPR139 agonist, supresses morphine intake
Function / Pharmacology:Potent and selective brain-penetrant GPR139 agonist (EC50=16 nM) an orphan G-protein-coupled receptor expressed in the CNS.1 Tritium-labeled JNJ-63533054 binds to cell membranes expressing GPR139 and can be displaced by putative endogenous ligands.2 Decreases compulsive-like alcohol drinking and hyperalgesia in alcohol-dependent rodents.3 Suppresses morphine intake in a mouse self-administration model.4
分子式:C17H17ClN2O2
分子量:316.78
溶剂:DMSO (35 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):GPR139 agonist, supresses morphine intake
Function / Pharmacology:Potent and selective brain-penetrant GPR139 agonist (EC50=16 nM) an orphan G-protein-coupled receptor expressed in the CNS.1 Tritium-labeled JNJ-63533054 binds to cell membranes expressing GPR139 and can be displaced by putative endogenous ligands.2 Decreases compulsive-like alcohol drinking and hyperalgesia in alcohol-dependent rodents.3 Suppresses morphine intake in a mouse self-administration model.4