纯度:98% by HPLC;NMR (Conforms)
分子式:C17H17ClN2O2
分子量:316.78
溶剂:DMSO (35 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):GPR139 agonist, supresses morphine intake
Function / Pharmacology:Potent and selective brain-penetrant GPR139 agonist (EC50=16 nM) an orphan G-protein-coupled receptor expressed in the CNS.1 Tritium-labeled JNJ-63533054 binds to cell membranes expressing GPR139 and can be displaced by putative endogenous ligands.2 Decreases compulsive-like alcohol drinking and hyperalgesia in alcohol-dependent rodents.3 Suppresses morphine intake in a mouse self-administration model.4