纯度:98% by HPLC;NMR (Conforms)
分子式:C16H17N7O2S
分子量:371.42
溶剂:DMSO (30 mg/ml) DMF (50 mg/ml)
性状:White or off-white solid
存储:-20°C
Activity (short version):JAK 1/2 inhibitor
Function / Pharmacology:Baricitinib, approved by the FDA for two inflammatory disorders, rheumatoid arthritis and alopecia areata, selectively inhibits Janus kinase 1 (IC50 = 5.9 nM) and 2 (5.7 nM), over 3 (0.56 μM).1 It thereby blocks JAK/STAT signaling, reducing cytokine release and suppressing the innate and adaptive immune systems.1,2 Was recently shown to significantly improve COVID-19 symptoms in a preliminary human trial, presumably through suppression of the cytokine release syndrome (“cytokine storm”) induced by SARS-CoV-2 infection.3