纯度:98% by HPLC;NMR (Conforms)
分子式:C22H24O4S
分子量:384.49
溶剂:DMSO (>25 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):PPARα/δ agonist
Function / Pharmacology:Elafibranor is a dual PPARalpha/delta agonist (EC50 PPARalpha = 10-20 nM; PPARdelta = 100-150 nM).1 It was able to decrease plasma triglycerides levels1, increase HDL cholesterol levels in human studies1, and improve hepatic and peripheral insulin sensitivity2. Elafibranor’s antidiabetic effects in db/db were without the adverse cardiac effects seen in PPARgamma agonism.3 Elafibranor has also been shown to have therapeutic promise in the treatment of nonalcoholic steatohepatitis (NASH).4-6