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Lipofermata
- 英文名称:Lipofermata
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B10989
- cas:297180-15-5
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B10989 |
用途 | 科研检测 |
英文名称 | Lipofermata |
包装规格 | 1MG |
CAS编号 | 297180-15-5 |
别名 | Lipofermata |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98%,;NMR (Conforms)
分子式:C15H10BrN3OS
分子量:360.23
溶剂:DMSO (20 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Fatty acid transport protein 2 (FATP2) inhibitor
Function / Pharmacology:Lipofermata is an inhibitor of fatty acid transport protein 2 (FATP2; IC50 = 4.84 μM).1 It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase. It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease.2 Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.3
分子式:C15H10BrN3OS
分子量:360.23
溶剂:DMSO (20 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Fatty acid transport protein 2 (FATP2) inhibitor
Function / Pharmacology:Lipofermata is an inhibitor of fatty acid transport protein 2 (FATP2; IC50 = 4.84 μM).1 It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase. It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease.2 Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.3