纯度:98%,;NMR (Conforms)
分子式:C15H10BrN3OS
分子量:360.23
溶剂:DMSO (20 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Fatty acid transport protein 2 (FATP2) inhibitor
Function / Pharmacology:Lipofermata is an inhibitor of fatty acid transport protein 2 (FATP2; IC50 = 4.84 μM).1 It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase. It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease.2 Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.3