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Lipofermata
  • 英文名称:Lipofermata
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B10989
  • cas:297180-15-5
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-23
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B10989
用途 科研检测
英文名称 Lipofermata
包装规格 1MG
CAS编号 297180-15-5
别名 Lipofermata
纯度 98+%
分子式
是否进口
纯度:98%,;NMR (Conforms)
分子式:C15H10BrN3OS
分子量:360.23
溶剂:DMSO (20 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):Fatty acid transport protein 2 (FATP2) inhibitor
Function / Pharmacology:Lipofermata is an inhibitor of fatty acid transport protein 2 (FATP2; IC50 = 4.84 μM).1 It does not inhibit glucose transport or the activity of long chain acyl-CoA synthetase. It prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and mINS-1E cells suggesting utility in preventing fatty acid-mediated cell death pathways and lipotoxic disease.2 Inhibition was specific for long and very long chain fatty acids but not medium (C6-C10) acids. Lipofermata abrogates lipid transport into melanoma cells and reduces melanoma growth and invasion.3
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