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SI-2
- 英文名称：SI-2
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B10990
- cas：380537-35-9
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B10990 |
| 用途 | 科研检测 |
| 英文名称 | SI-2 |
| 包装规格 | 1MG |
| CAS编号 | 380537-35-9 |
| 别名 | SI-2 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC;NMR (Conforms)
分子式:C15H15N5
分子量:265.31
溶剂:DMSO (20 mg/ml)
性状:Pale orange solid
存储:-20°C
Activity (short version):Potent inhibitor of steroid receptor coactivator-3 (SRC-3)
Function / Pharmacology:Si-2 is a potent inhibitor of steroid receptor coactivator-3 (SRC-3).1 It blocks MDA-MB-468 cell growth with an IC50 = 3.4 nM without effecting normal cells.1 It significantly inhibited breast cancer cell growth in an orthotopic MDA-MD-468 mouse model. Treatment of MCF-7 or triple negative MDA-MB-231 cells with SI-2 resulted in inhibition of proliferation and breast cancer stem cell (CSC) tumorsphere formation.2 CSC markers CD44+/CD24-/1o and aldehyde dehydrogenase (ALDH) were also reduced indicating that SI-2 can selectively interfere with the TIC/CSC state in breast cancer cells.2,3
分子式:C15H15N5
分子量:265.31
溶剂:DMSO (20 mg/ml)
性状:Pale orange solid
存储:-20°C
Activity (short version):Potent inhibitor of steroid receptor coactivator-3 (SRC-3)
Function / Pharmacology:Si-2 is a potent inhibitor of steroid receptor coactivator-3 (SRC-3).1 It blocks MDA-MB-468 cell growth with an IC50 = 3.4 nM without effecting normal cells.1 It significantly inhibited breast cancer cell growth in an orthotopic MDA-MD-468 mouse model. Treatment of MCF-7 or triple negative MDA-MB-231 cells with SI-2 resulted in inhibition of proliferation and breast cancer stem cell (CSC) tumorsphere formation.2 CSC markers CD44+/CD24-/1o and aldehyde dehydrogenase (ALDH) were also reduced indicating that SI-2 can selectively interfere with the TIC/CSC state in breast cancer cells.2,3
