纯度:98% by HPLC;NMR (Conforms)
分子式:C12H20N2O7
分子量:304.30
溶剂:DMSO (>25 mg/ml) Water (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Potent inhibitor glutamate carboxypeptidases II and III
Function / Pharmacology:ZJ43 is potent inhibitor of glutamate carboxypeptidases II (Ki = 0.8 nM) and III (Ki = 23 nM).1 It blocks MDA-MB-468 cell growth with an IC50 = 3.4 nM without effecting normal cells.1 It potently (IC50 = 2.4 nM) inhibited the ability of glutamate carboxypeptidase II to hydrolyze the neurotransmitter N-acetylaspartylglutamate (NAAG) resulting in an increase in synaptic levels of group II mGluRs. Peripherally administered ZJ43 increased the activation of mGluR3 by NAAG released from peripheral sensory neurites resulting in analgesia.2,3 ZJ43 has also shown efficacy in other inflammatory pain models.4,5