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Iberdomide
  • 英文名称:Iberdomide
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11004
  • cas:1323403-33-3
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-12
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11004
用途 科研检测
英文名称 Iberdomide
包装规格 1MG
CAS编号 1323403-33-3
别名 Iberdomide
纯度 98+%
分子式
是否进口
纯度:>98% by HPLC ,;NMR (Conforms)
分子式:C25H27N3O5
分子量:449.51
溶剂:DMSO (50 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Cereblon modulator/Molecular glue
Function / Pharmacology:Iberdomide is a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex with higher affinity (IC50 = 60 nM) than lenalidomide and pomalidomide leading to more potent degradation of Ikaros (IKZF1; EC50 = 1 nM)) and Aiolos (IKZF3; EC50 = 0.5 nM).1 It is more specific for the cereblon complex and does not degrade GSPT1 of CK1α. It displays antitumor and immunostimulatory activity in lenalidomide- and pomalidomide-resistant multiple myeloma cells.2 Iberdomide has also shown efficacy in treating the autoimmune disease cutaneous lupus erythematosus (CLE).3 It was also shown to act as an HIV-1 latency reversal agent in in CD4+ T-cells.4
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