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CIB-3b
- 英文名称：CIB-3b
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11006
- cas：124811-87-6
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-07-16
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11006 |
| 用途 | 科研检测 |
| 英文名称 | CIB-3b |
| 包装规格 | 1MG |
| CAS编号 | 124811-87-6 |
| 别名 | CIB-3b |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC ,;NMR (Conforms)
分子式:C14H15NO4
分子量:261.28
溶剂:DMSO (25 mg/ml) Ethanol (30 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Inhibitor of microRNA biogenesis
Function / Pharmacology:CIB-3b inhibits microRNA (miRNA) biogenesis via binding (KD = 10.42 nM) to transactivation response (TAR) RNA-binding protein 2 (TRBP), disrupting the TRBP-Dicer interaction, a critical element in pre-miRNA processing. It inhibited mi-R21 (EC50 = 1.38 μM) expression, a potent inducer of cellular EMT progression. CIB-3b inhibited hepatocarcinogenesis by blocking EMT in a mouse orthotopic transplantation model (SK-HEP-1 cells).
分子式:C14H15NO4
分子量:261.28
溶剂:DMSO (25 mg/ml) Ethanol (30 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Inhibitor of microRNA biogenesis
Function / Pharmacology:CIB-3b inhibits microRNA (miRNA) biogenesis via binding (KD = 10.42 nM) to transactivation response (TAR) RNA-binding protein 2 (TRBP), disrupting the TRBP-Dicer interaction, a critical element in pre-miRNA processing. It inhibited mi-R21 (EC50 = 1.38 μM) expression, a potent inducer of cellular EMT progression. CIB-3b inhibited hepatocarcinogenesis by blocking EMT in a mouse orthotopic transplantation model (SK-HEP-1 cells).
