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PY-60
- 英文名称:PY-60
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11007
- cas:2765218-56-0
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11007 |
用途 | 科研检测 |
英文名称 | PY-60 |
包装规格 | 1MG |
CAS编号 | 2765218-56-0 |
别名 | PY-60 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by HPLC ,;NMR (Conforms)
分子式:C16H15N3O2S
分子量:313.38
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):YAP Activator
Function / Pharmacology:PY-60 (2765218-56-0) activates YAP transcriptional activity (EC50 = 1.6 μM) via delocalization of annexin A2 (ANXA2) from cell membranes leading to Hippo inactivation, a key controller of YAP.1 It was able to induce serum-free expansion of MCF10A cells and epidermal keratinocytes and their precursors ex vivo and in adult mice. PY-60 promoted regenerative repair of cutaneous wounds in pig and human models by enabling a pro-proliferative transcriptional program in keratinocytes and dermal cells that accelerated re-epithelization and regranulation of the wound bed.2
分子式:C16H15N3O2S
分子量:313.38
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):YAP Activator
Function / Pharmacology:PY-60 (2765218-56-0) activates YAP transcriptional activity (EC50 = 1.6 μM) via delocalization of annexin A2 (ANXA2) from cell membranes leading to Hippo inactivation, a key controller of YAP.1 It was able to induce serum-free expansion of MCF10A cells and epidermal keratinocytes and their precursors ex vivo and in adult mice. PY-60 promoted regenerative repair of cutaneous wounds in pig and human models by enabling a pro-proliferative transcriptional program in keratinocytes and dermal cells that accelerated re-epithelization and regranulation of the wound bed.2