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AMG 510
- 英文名称：AMG 510
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11011
- cas：2296729-00-3
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11011 |
| 用途 | 科研检测 |
| 英文名称 | AMG 510 |
| 包装规格 | 1MG |
| CAS编号 | 2296729-00-3 |
| 别名 | AMG 510 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC ,;NMR (Conforms)
分子式:C30H30F2N6O3
分子量:560.61
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Covalent KRASG12C Inhibitor
Function / Pharmacology:AMG 510 is a potent (IC50’s = 6 nM NCI-H358; 9 nM MIA PaCa-2) covalent KRASG12C inhibitor.1,2 It significantly inhibited tumor growth in NCI-H358 and MIA PaCa-2 cell lines as well as CT-26 tumors (mouse syngeneic model) and caused tumor regression at higher doses.1 AMG 510 improved the efficacy of various other chemotherapeutic agents including inhibitors of HER kinases, EGFR, SHP2, PI3K, AKT, and MEK 1,3 and synergized with immune checkpoint reagents1. FDA approved for use in KRASG12C-positive non-small cell lung cancer. AMG 510 displayed efficacy alone4,5 and in combination5 with trametinib and/or buparlisib in pancreatic ductal adenocarcinoma cell lines.
分子式:C30H30F2N6O3
分子量:560.61
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Covalent KRASG12C Inhibitor
Function / Pharmacology:AMG 510 is a potent (IC50’s = 6 nM NCI-H358; 9 nM MIA PaCa-2) covalent KRASG12C inhibitor.1,2 It significantly inhibited tumor growth in NCI-H358 and MIA PaCa-2 cell lines as well as CT-26 tumors (mouse syngeneic model) and caused tumor regression at higher doses.1 AMG 510 improved the efficacy of various other chemotherapeutic agents including inhibitors of HER kinases, EGFR, SHP2, PI3K, AKT, and MEK 1,3 and synergized with immune checkpoint reagents1. FDA approved for use in KRASG12C-positive non-small cell lung cancer. AMG 510 displayed efficacy alone4,5 and in combination5 with trametinib and/or buparlisib in pancreatic ductal adenocarcinoma cell lines.
