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SJ6986
- 英文名称：SJ6986
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11013
- cas：2765625-93-0
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11013 |
| 用途 | 科研检测 |
| 英文名称 | SJ6986 |
| 包装规格 | 1MG |
| CAS编号 | 2765625-93-0 |
| 别名 | SJ6986 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:98% by HPLC ,;NMR (Conforms)
分子式:C20H14F3N3O5
分子量:433.34
溶剂:DMSO (>40 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):GSPT1 molecular glue
Function / Pharmacology:SJ6986 is a potent (IC50 = 15 nM for Cereblon; EC50 = 1.5 nM for MV4-11 AML cells), selective, and orally bioavailable molecular glue degrader of the small GTPases G1 to S phase transition 1/2 (GSPT1/2).1 It displayed selectivity for GPST1/2 over 9000 other proteins including the classic cereblon substrates IKZF1 (Ikaros) and IZKF3 (Aiolos). SJ6986 displayed efficacy against acute lymphoblastic leukemia cell lines and xenografts.2
分子式:C20H14F3N3O5
分子量:433.34
溶剂:DMSO (>40 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):GSPT1 molecular glue
Function / Pharmacology:SJ6986 is a potent (IC50 = 15 nM for Cereblon; EC50 = 1.5 nM for MV4-11 AML cells), selective, and orally bioavailable molecular glue degrader of the small GTPases G1 to S phase transition 1/2 (GSPT1/2).1 It displayed selectivity for GPST1/2 over 9000 other proteins including the classic cereblon substrates IKZF1 (Ikaros) and IZKF3 (Aiolos). SJ6986 displayed efficacy against acute lymphoblastic leukemia cell lines and xenografts.2
