纯度:98% by HPLC ,;NMR (Conforms)
分子式:C17H12N4O2S
分子量:336.37
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):RBM39 molecular glue
Function / Pharmacology:E7820 is an angiogenesis inhibitor that suppresses expression of integrins α2, α3, α5, and ?1.1 Broad-spectrum antitumor and antiangiogenic effects are mainly mediated via integrin α2 suppression.2 E7820 has been identified as a molecular glue that induces proteasomal degradation of the U2AF-related splicing factor CAPERα (RBM39) via CRL4DCAF15 mediated ubiquitination in human cancer cell lines.3,4 E7820 has also been shown to induce degradation of the aryl hydrocarbon receptor nuclear translator (ARNT), a protein essential in maintaining cellular homeostasis in response to environmental stress.5