![]() |
E7820
- 英文名称:E7820
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11014
- cas:289483-69-8
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-12
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11014 |
用途 | 科研检测 |
英文名称 | E7820 |
包装规格 | 1MG |
CAS编号 | 289483-69-8 |
别名 | E7820 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:98% by HPLC ,;NMR (Conforms)
分子式:C17H12N4O2S
分子量:336.37
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):RBM39 molecular glue
Function / Pharmacology:E7820 is an angiogenesis inhibitor that suppresses expression of integrins α2, α3, α5, and ?1.1 Broad-spectrum antitumor and antiangiogenic effects are mainly mediated via integrin α2 suppression.2 E7820 has been identified as a molecular glue that induces proteasomal degradation of the U2AF-related splicing factor CAPERα (RBM39) via CRL4DCAF15 mediated ubiquitination in human cancer cell lines.3,4 E7820 has also been shown to induce degradation of the aryl hydrocarbon receptor nuclear translator (ARNT), a protein essential in maintaining cellular homeostasis in response to environmental stress.5
分子式:C17H12N4O2S
分子量:336.37
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):RBM39 molecular glue
Function / Pharmacology:E7820 is an angiogenesis inhibitor that suppresses expression of integrins α2, α3, α5, and ?1.1 Broad-spectrum antitumor and antiangiogenic effects are mainly mediated via integrin α2 suppression.2 E7820 has been identified as a molecular glue that induces proteasomal degradation of the U2AF-related splicing factor CAPERα (RBM39) via CRL4DCAF15 mediated ubiquitination in human cancer cell lines.3,4 E7820 has also been shown to induce degradation of the aryl hydrocarbon receptor nuclear translator (ARNT), a protein essential in maintaining cellular homeostasis in response to environmental stress.5