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E7820
  • 英文名称:E7820
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11014
  • cas:289483-69-8
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-12
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11014
用途 科研检测
英文名称 E7820
包装规格 1MG
CAS编号 289483-69-8
别名 E7820
纯度 98+%
分子式
是否进口
纯度:98% by HPLC ,;NMR (Conforms)
分子式:C17H12N4O2S
分子量:336.37
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):RBM39 molecular glue
Function / Pharmacology:E7820 is an angiogenesis inhibitor that suppresses expression of integrins α2, α3, α5, and ?1.1 Broad-spectrum antitumor and antiangiogenic effects are mainly mediated via integrin α2 suppression.2 E7820 has been identified as a molecular glue that induces proteasomal degradation of the U2AF-related splicing factor CAPERα (RBM39) via CRL4DCAF15 mediated ubiquitination in human cancer cell lines.3,4 E7820 has also been shown to induce degradation of the aryl hydrocarbon receptor nuclear translator (ARNT), a protein essential in maintaining cellular homeostasis in response to environmental stress.5
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