纯度:>98% by HPLC ,;NMR (Conforms)
分子式:C11H13ClN2O3S
分子量:288.75
溶剂:DMSO (>80 mg/ml)
性状:White to off-white solid
存储:-20°C
Activity (short version):NFkB1 molecular glue
Function / Pharmacology:EN450 is a molecular glue that covalently interacts with a cysteine residue on the E2 ubiquitin ligase UBE2D. It displayed anti-proliferative effects in HAP1 leukemia cells. EN450s antiproliferative effects were elicited via proteasome-dependent degradation of nuclear factor kappa B subunit 1(NFkB1).1