纯度:99% by HPLC;NMR (Conforms)
分子式:C18H20N2O4S
分子量:360.43
溶剂:DMSO (>25 mg/ml); ethanol (5 mg/mL with warming)
性状:White solid
存储:-20°C
Activity (short version):MRGPRX1 positive allosteric modulator
Function / Pharmacology:ML382 is a potent (EC50 = 190 nM in the presence of the endogenous peptide MRGX1 agonist BAM8-22) and selective positive allosteric modulator of the Mas-related G protein-coupled receptor X1 (MRGX1 or MRGPRX1), a receptor whose expression is limited to subsets of small-diameter sensory neurons in dorsal root ganglia and trigeminal neurons.1 ML382 significantly enhanced the antihyperalgesic effects of exogenously added BAM8-22 and in mouse models of persistent pain without exogenous BAM8-22, suggesting enhanced pain inhibition from a sufficient supply of endogenous MRGPRX1 ligands and a potential new pain therapeutic.2