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ML382
- 英文名称:ML382
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11016
- cas:1646499-97-9
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11016 |
用途 | 科研检测 |
英文名称 | ML382 |
包装规格 | 1MG |
CAS编号 | 1646499-97-9 |
别名 | ML382 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:99% by HPLC;NMR (Conforms)
分子式:C18H20N2O4S
分子量:360.43
溶剂:DMSO (>25 mg/ml); ethanol (5 mg/mL with warming)
性状:White solid
存储:-20°C
Activity (short version):MRGPRX1 positive allosteric modulator
Function / Pharmacology:ML382 is a potent (EC50 = 190 nM in the presence of the endogenous peptide MRGX1 agonist BAM8-22) and selective positive allosteric modulator of the Mas-related G protein-coupled receptor X1 (MRGX1 or MRGPRX1), a receptor whose expression is limited to subsets of small-diameter sensory neurons in dorsal root ganglia and trigeminal neurons.1 ML382 significantly enhanced the antihyperalgesic effects of exogenously added BAM8-22 and in mouse models of persistent pain without exogenous BAM8-22, suggesting enhanced pain inhibition from a sufficient supply of endogenous MRGPRX1 ligands and a potential new pain therapeutic.2
分子式:C18H20N2O4S
分子量:360.43
溶剂:DMSO (>25 mg/ml); ethanol (5 mg/mL with warming)
性状:White solid
存储:-20°C
Activity (short version):MRGPRX1 positive allosteric modulator
Function / Pharmacology:ML382 is a potent (EC50 = 190 nM in the presence of the endogenous peptide MRGX1 agonist BAM8-22) and selective positive allosteric modulator of the Mas-related G protein-coupled receptor X1 (MRGX1 or MRGPRX1), a receptor whose expression is limited to subsets of small-diameter sensory neurons in dorsal root ganglia and trigeminal neurons.1 ML382 significantly enhanced the antihyperalgesic effects of exogenously added BAM8-22 and in mouse models of persistent pain without exogenous BAM8-22, suggesting enhanced pain inhibition from a sufficient supply of endogenous MRGPRX1 ligands and a potential new pain therapeutic.2