纯度:>98% by HPLC ,;NMR (Conforms)
分子式:C18H14N2O2
分子量:290.32
溶剂:DMSO (75 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):pan-ERR agonist/Exercise mimetic
Function / Pharmacology:Pan-agonist of the estrogen receptor-related receptors (EC50’s cell-based cotransfection/reporter assay: ERRα = 98 nM, ERR? = 230 nM, ERRγ = 430 nM) with highest potency for ERRα.1,2 SLU-PP-332 increased mitochondrial function and cellular respiration in a skeletal muscle cell line.2 It also increased fast oxidative skeletal muscle fibers (Type IIa) and exercise endurance in mice in an ERRα-specific manner. SLU-PP-332 activates an acute aerobic exercise genetic response via inducing the expression of DDIT4.2