纯度:>98% by HPLC;NMR (Conforms)
分子式:C47H60N8O6S
分子量:865.11
溶剂:DMSO (>75 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):KRAS inhibitor
Function / Pharmacology:RMC-7977 is broad spectrum inhibitor of both mutant and wild-type KRAS, NRAS, and HRAS variants.1 It binds with high affinity to cyclophilin A (KD = 195 nM) creating a binary complex that has high affinity for the active state of KRAS (KD = 85 nM for G12V). Active in in vivo xenograft models of NSCLC, CRC, and PDAC.1,2,3 RMC-7977 was able to overcome resistance to the KRASG12D selective inhibitor MRTX1133.1