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BI-3406
- 英文名称:BI-3406
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11028
- cas:2230836-55-0
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-23
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11028 |
用途 | 科研检测 |
英文名称 | BI-3406 |
包装规格 | 1MG |
CAS编号 | 2230836-55-0 |
别名 | BI-3406 |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C23H25F3N4O3
分子量:462.47
溶剂:DMSO (>70 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):SOS1 inhibitor
Function / Pharmacology:BI-3406 is a potent (IC50 = 5 nM), selective, and orally bioavailable SOS1 inhibitor.1 It blocks SOS1 interaction with KRAS preventing activation of KRAS. BI-3406 was active against multiple cancer cell types and xenograft models harboring various KRAS mutant alleles including G12C,V,S,A,and G13D. It displayed strong synergistic effects with the MEK inhibitor trametinib1,2 and this combination was able to overcome resistance to the KRAS inhibitors sotorasib and adagrasib3. BI-3406 acted synergistically with the KRAS inhibitor adagrasib in KRAS G12C mutant lung and colorectal cancer models.4
分子式:C23H25F3N4O3
分子量:462.47
溶剂:DMSO (>70 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):SOS1 inhibitor
Function / Pharmacology:BI-3406 is a potent (IC50 = 5 nM), selective, and orally bioavailable SOS1 inhibitor.1 It blocks SOS1 interaction with KRAS preventing activation of KRAS. BI-3406 was active against multiple cancer cell types and xenograft models harboring various KRAS mutant alleles including G12C,V,S,A,and G13D. It displayed strong synergistic effects with the MEK inhibitor trametinib1,2 and this combination was able to overcome resistance to the KRAS inhibitors sotorasib and adagrasib3. BI-3406 acted synergistically with the KRAS inhibitor adagrasib in KRAS G12C mutant lung and colorectal cancer models.4