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PF-06835919
- 英文名称：PF-06835919
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11029
- cas：2102501-84-6
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11029 |
| 用途 | 科研检测 |
| 英文名称 | PF-06835919 |
| 包装规格 | 1MG |
| CAS编号 | 2102501-84-6 |
| 别名 | PF-06835919 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC,;NMR (Conforms)
分子式:C16H19F3N4O2
分子量:356.35
溶剂:DMSO (10 mg/ml with warming)
性状:White solid
存储:-20°C
Activity (short version):Ketohexokinase inhibitor
Function / Pharmacology:PF-06835919 is a potent (IC50 = 10 nM KHK-C; 170 nM KHK-A) inhibitor of ketohexokinase (KHK), the first enzyme in the fructose metabolic cascade.1 It displayed high selectivity against other sugar kinases. PF-06835919 prevented hyperinsulinemia, hypertriglyceridemia, and hepatic steatosis in fructose-fed rats.2 The increased tumor proliferation effect of fructose in CaSki cells was inhibited by PF-06835919.3 An interesting new tool to study metabolic and fatty liver diseases.
分子式:C16H19F3N4O2
分子量:356.35
溶剂:DMSO (10 mg/ml with warming)
性状:White solid
存储:-20°C
Activity (short version):Ketohexokinase inhibitor
Function / Pharmacology:PF-06835919 is a potent (IC50 = 10 nM KHK-C; 170 nM KHK-A) inhibitor of ketohexokinase (KHK), the first enzyme in the fructose metabolic cascade.1 It displayed high selectivity against other sugar kinases. PF-06835919 prevented hyperinsulinemia, hypertriglyceridemia, and hepatic steatosis in fructose-fed rats.2 The increased tumor proliferation effect of fructose in CaSki cells was inhibited by PF-06835919.3 An interesting new tool to study metabolic and fatty liver diseases.
