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Trametiglue
- 英文名称:Trametiglue
- 品牌:WYTSCI
- 产地:进口
- 型号:1MG
- 货号:WT-AY-B11031
- cas:2666940-97-0
- 价格: ¥1/mg
- 发布日期: 2025-04-10
- 更新日期: 2025-05-12
产品详请
产地 | 进口 |
品牌 | WYTSCI |
货号 | WT-AY-B11031 |
用途 | 科研检测 |
英文名称 | Trametiglue |
包装规格 | 1MG |
CAS编号 | 2666940-97-0 |
别名 | Trametiglue |
纯度 | 98+% |
分子式 | |
是否进口 | 是 |
纯度:>98% by TLC;NMR (Conforms)
分子式:C25H24FIN6O5S
分子量:666.47
溶剂:DMSO (>25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):MEK inhibitor / molecular glue
Function / Pharmacology:Trametiglue is a trametinib analog that inhibits both KSR- and RAF-bound MEK and limits adaptive resistance seen with trametinib via enhanced interfacial binding. Displays significantly enhanced inhibition of RAS/ERK signaling versus trametinib is various cell lines with mutant KRAS and BRAF: IC50’s/cell line – SK-MEL-239/0.47 nM; HCT116/0.07 nM; A549/0.12 nM; A375/0.07 nM. A molecular glue that is strongly selective towards MEK with no direct interaction with BRAF or CRAF.
分子式:C25H24FIN6O5S
分子量:666.47
溶剂:DMSO (>25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):MEK inhibitor / molecular glue
Function / Pharmacology:Trametiglue is a trametinib analog that inhibits both KSR- and RAF-bound MEK and limits adaptive resistance seen with trametinib via enhanced interfacial binding. Displays significantly enhanced inhibition of RAS/ERK signaling versus trametinib is various cell lines with mutant KRAS and BRAF: IC50’s/cell line – SK-MEL-239/0.47 nM; HCT116/0.07 nM; A549/0.12 nM; A375/0.07 nM. A molecular glue that is strongly selective towards MEK with no direct interaction with BRAF or CRAF.