|
Trametiglue
- 英文名称：Trametiglue
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11031
- cas：2666940-97-0
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-12
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11031 |
| 用途 | 科研检测 |
| 英文名称 | Trametiglue |
| 包装规格 | 1MG |
| CAS编号 | 2666940-97-0 |
| 别名 | Trametiglue |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by TLC;NMR (Conforms)
分子式:C25H24FIN6O5S
分子量:666.47
溶剂:DMSO (>25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):MEK inhibitor / molecular glue
Function / Pharmacology:Trametiglue is a trametinib analog that inhibits both KSR- and RAF-bound MEK and limits adaptive resistance seen with trametinib via enhanced interfacial binding. Displays significantly enhanced inhibition of RAS/ERK signaling versus trametinib is various cell lines with mutant KRAS and BRAF: IC50’s/cell line – SK-MEL-239/0.47 nM; HCT116/0.07 nM; A549/0.12 nM; A375/0.07 nM. A molecular glue that is strongly selective towards MEK with no direct interaction with BRAF or CRAF.
分子式:C25H24FIN6O5S
分子量:666.47
溶剂:DMSO (>25 mg/ml)
性状:Off-white solid
存储:-20°C
Activity (short version):MEK inhibitor / molecular glue
Function / Pharmacology:Trametiglue is a trametinib analog that inhibits both KSR- and RAF-bound MEK and limits adaptive resistance seen with trametinib via enhanced interfacial binding. Displays significantly enhanced inhibition of RAS/ERK signaling versus trametinib is various cell lines with mutant KRAS and BRAF: IC50’s/cell line – SK-MEL-239/0.47 nM; HCT116/0.07 nM; A549/0.12 nM; A375/0.07 nM. A molecular glue that is strongly selective towards MEK with no direct interaction with BRAF or CRAF.
