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PT-179
- 英文名称：PT-179
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11032
- cas：2924858-25-1
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-23
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11032 |
| 用途 | 科研检测 |
| 英文名称 | PT-179 |
| 包装规格 | 1MG |
| CAS编号 | 2924858-25-1 |
| 别名 | PT-179 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC;NMR (Conforms)
分子式:C17 H17N3O5
分子量:343.34
溶剂:DMSO (>50 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Thalidomide analog molecular glue
Function / Pharmacology:PT-179 is an orthogonal thalidomide analog that binds cereblon (CRBN: KD = 587 nM; pomalidomide KD = 500 nM) with greatly reduced off-target activity compared to pomalidomide. Pomalidomide induced differential expression of 1426 genes in MM.1S multiple myeloma cells compared to only 3 for PT-179. PT-179 is an interesting new tool for exploring CRBN-based therapeutics.
分子式:C17 H17N3O5
分子量:343.34
溶剂:DMSO (>50 mg/ml)
性状:Yellow solid
存储:-20°C
Activity (short version):Thalidomide analog molecular glue
Function / Pharmacology:PT-179 is an orthogonal thalidomide analog that binds cereblon (CRBN: KD = 587 nM; pomalidomide KD = 500 nM) with greatly reduced off-target activity compared to pomalidomide. Pomalidomide induced differential expression of 1426 genes in MM.1S multiple myeloma cells compared to only 3 for PT-179. PT-179 is an interesting new tool for exploring CRBN-based therapeutics.
