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WX-02-23
- 英文名称：WX-02-23
- 品牌：WYTSCI
- 产地：进口
- 型号：1MG
- 货号：WT-AY-B11035
- cas：2929223-35-6
- 价格： ￥1/mg
- 发布日期： 2025-04-10
- 更新日期： 2025-05-16
产品详请
| 产地 | 进口 |
| 品牌 | WYTSCI |
| 货号 | WT-AY-B11035 |
| 用途 | 科研检测 |
| 英文名称 | WX-02-23 |
| 包装规格 | 1MG |
| CAS编号 | 2929223-35-6 |
| 别名 | WX-02-23 |
| 纯度 | 98+% |
| 分子式 | |
| 是否进口 | 是 |
纯度:>98% by HPLC,;NMR (Conforms)
分子式:C26H25N3O5
分子量:459.5
溶剂:DMSO (>70 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):Spliceosome/FOXA1 modulator
Function / Pharmacology:WX-02-23 is a spliceosome modulator. It binds to the spliceosome factor SF3B1 stabilizing a spliceosome state with enhanced binding to DDX42. WX-02-23 displayed anti-proliferative effects in Panc 05.04 and Panc 04.03 cells.1 WX-02-23 also modulates the pioneer transcription factor FOXA1 via covalent binding to Cysteine 258 in a DNA-dependent manner (EC50 = 2 μM FOXA1; 12 μM FOXA1-FKHD). It alters activity via relaxation of FOXA1s DNA-binding motif changing chromatin accessibility.2
分子式:C26H25N3O5
分子量:459.5
溶剂:DMSO (>70 mg/ml)
性状:Pale yellow solid
存储:-20°C
Activity (short version):Spliceosome/FOXA1 modulator
Function / Pharmacology:WX-02-23 is a spliceosome modulator. It binds to the spliceosome factor SF3B1 stabilizing a spliceosome state with enhanced binding to DDX42. WX-02-23 displayed anti-proliferative effects in Panc 05.04 and Panc 04.03 cells.1 WX-02-23 also modulates the pioneer transcription factor FOXA1 via covalent binding to Cysteine 258 in a DNA-dependent manner (EC50 = 2 μM FOXA1; 12 μM FOXA1-FKHD). It alters activity via relaxation of FOXA1s DNA-binding motif changing chromatin accessibility.2
