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Compound 147
  • 英文名称:Compound 147
  • 品牌:WYTSCI
  • 产地:进口
  • 型号:1MG
  • 货号:WT-AY-B11039
  • cas:393121-74-9
  • 价格: ¥1/mg
  • 发布日期: 2025-04-10
  • 更新日期: 2025-05-12
产品详请
产地 进口
品牌 WYTSCI
货号 WT-AY-B11039
用途 科研检测
英文名称 Compound 147
包装规格 1MG
CAS编号 393121-74-9
别名 Compound 147
纯度 98+%
分子式
是否进口
纯度:98% by HPLC ,;NMR (Conforms)
分子式:C16H17NO2
分子量:255.32
溶剂:DMSO (>25 mg/ml); ethanol (>25 mg/mL)
性状:Beige to pale orange solid
存储:-20°C
Activity (short version):ER stress sensing protein ATF6 activator
Function / Pharmacology:Preferential activator of the ER stress sensing protein ATF6.1 It was able to selectively reduce secretion and extracellular aggregation of destabilized amyloidogenic variants of TTR and LC proteins. AA147-dependent ATF6 activation proceeds via metabolic activation to a reactive electrophile that selectively modifies ER proteins including multiple protein disulfide isomerases.2 AA147 suppressed pluripotency and promoted human stem cell differentiation toward a mesodermal lineage via ER expansion.3 It protected the heart against ischemia/reperfusion (I/R) injury in a mouse model of acute myocardial infarction in an ATF6-dependent manner.4 Brain, kidney, and liver tissue was also protected from I/R damage and impaired proteostasis. AA147 reduced infection of multiple strains of dengue and Zika viruses in an ATF6-independent manner.5 Protects against glutamate-induced cell death is a neuronal-derived cell culture model.6 See companion inhibitor 10-3974.
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