纯度:98% by HPLC ,;NMR (Conforms)
分子式:C17H16BrF3N4O
分子量:429.24
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):TRPV1 antagonist
Function / Pharmacology:Potent and selective antagonist of the TRPV1 receptor (IC50’s for receptor induction method: Capsaicin = 3 nM; Acid (pH5.3) = pIC50 7.1, and Heat = 6 nM) with activity in human, rat, and guinea pig receptors.1,2 SB-705498s activity is voltage dependent and shows >100 fold selectivity over the closely related TRPM8 receptor.2