纯度:98% by HPLC;NMR (Conforms)
分子式:C18H12Cl2FN5O3S2
分子量:500.34
溶剂:DMSO (>25 mg/ml)
性状:White solid
存储:-20°C
Activity (short version):Selective Nav1.7 channel blocker
Function / Pharmacology:Potent and selective inhibitor of the voltage gated sodium channel 1.7 (Nav1.7).1,3 It is a state-dependent inhibitor with IC50 = 11 nM for the half-inactivated channels and IC50 ~ 10 μM for resting channels.1 Equipotent for human, monkey, dog, and mouse channels but 15x less potent for rat channels. Interacts equally with fast and slow inactivated Nav1.7 channels.2