纯度:99% by HPLC,;NMR (Conforms)
分子式:C22H20Cl2N4O4
分子量:475.32
溶剂:DMSO (>30 mg/ml)
性状:White solid
存储:RT
Activity (short version):GPX4 inhibitor / Ferroptosis inducer
Function / Pharmacology:ML210 is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able to inhibit glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron catalyzed formation of free radicals from lipid peroxides.2,3 Treatment of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state with ML210 resulted in selective induction of ferroptosis.3