纯度:98% by TLC;NMR (Conforms)
分子式:C15H23NO2S
分子量:281.41
溶剂:DMSO (>25 mg/mL)
性状:Off-white solid
存储:RT
Activity (short version):Sigma-1 ligand/neuroprotective/restorative
Function / Pharmacology:Pridopidine is being studied as a potential treatment for Huntington’s disease, Parkinson’s disease, and schizophrenia based on its locomotor stabilizing and antipsychotic-like effects.1,2 It was, unusually, able to reverse both hypo- and hyperdopaminergia depending on local dopamine concentrations without inducing catalepsy. This was originally attributed to functional dopamine D2 antagonism with fast on/off kinetics (“dopamine stabilizer”).3 More recent studies have attributed pridopidine's effects to its being a more potent sigma-1 ligand than a D2 ligand.4,5 Displays neuroprotective/restorative effects6,7 and ameliorates central features of amyotrophic lateral sclerosis pathology8 in a sigma-1-mediated manner